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Adsorptive Stripping Voltammetric Determination of Albendazole at a Hanging Mercury Drop Electrode

Authors: 
Ali Z. Abu Zuhri
A. Hussain
M. Musmar
S. Yaish
Journal Name: 
Analytical Letters
Volume: 
32
Issue: 
15
Pages From: 
2965
To: 
2975
Date: 
Friday, January 1, 1999
Keywords: 
Adsorptive voltammetry, albendazole determination, hanging mercury drop
Abstract: 
Albendazole is determined by differential-pulse adsorptive cathodic stripping voltammetry at a hanging mercury drop electrode using the reduction peak of its copper(II) complex at −0.28V at an accumulation potential 0.0V vs. Ag/AgCl electrode. The optimum conditions of pH, accumulation potential and accumulation time were studied. The calibration graph for the determination of albendazole was linear in the range 3.0X10−8 - 9X10−7M with a relative standard deviation of 2.8%. The detection limit was 1.0X10−8M after 180s accumulation at 0.0V. The effect of common excipients and metal ions on the peak height of albendazole was studied. The presence of Cu2+ ions forms a stable complex with albendazole which is strongly adsorbed at the mercury electrode surface. The method was applied to the determination of the drug in commercially available dosage forms.