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Electrochemical Study on the Determination of Tinidazole in Tablets

Authors: 
Ali Z. Abu Zuhri
Suleiman Al- Khalil
Raqi Shubeitah
Ibrahim El-Hroub
Journal Name: 
Journal of Pharmaceutical and Biomedical Analysis
Volume: 
21
Issue: 
4
Pages From: 
881
To: 
886
Date: 
Wednesday, December 1, 1999
Keywords: 
Tinidazole determinationDifferential-pulse polarographyPharmaceutical formulations
Abstract: 
The electrochemical reduction of tinidazole has been carried out in aqueous solution in the pH range 1.8–11.3 by differential-pulse (DP) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In strongly acidic solution (pH<4.5), one reduction peak was obtained and it was suitable for analytical purposes. A method for the determination of tinidazole by DP polarography in Britton–Robinson buffer of pH 3.0, which allows quantification over the range 0.03–7.30 μg/ml, was proposed. The method was successfully applied to the determination of tinidazole in tablets with mean recovery and relative standard deviation of 98.7 and 3%, respectively. Excipients did not interfere in the determination.