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Development of degradable polyesterurethanes for medical applications: in vitro and in vivo evaluations

Authors: 
B Saad, TD Hirt, M Welti, GK Uhlschmid, P Neuenschwander, UW Suter
Journal Name: 
Journal of Biomedical Materials Research Part A
Volume: 
36
Issue: 
1
Pages From: 
65
To: 
74
Date: 
Tuesday, July 1, 1997
Abstract: 
To evaluate the biocompatibility of a newly developed degradable class of polyesterurethanes and their possible use as biomaterials, we investigated the cell and tissue interactions with these polymers using a small number of chemical base entities. The polymers were prepared by chain extension with diisocyanates of PHB/HV-diol and either PCL-diol or Diorez, another aliphatic polyester-diol. Regardless of the chemical composition of the four tested polyesterurethanes used as substrates, no morphological difference was ...