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Optimization of a Cultural Medium for Antifungal Antibiotic Production by Strain no.10/2(S. albovinaceus)

Authors: 
Thaer Abdelghani, Ellaiah Poluri
Journal Name: 
IJPI’s Journal of Biotechnology and Biotherapeutics
Volume: 
3
Issue: 
12
Pages From: 
1
To: 
15
Date: 
Monday, April 1, 2013
Keywords: 
Optimization, Streptomyces, S. albovinaceus, antifungal.
Abstract: 
A broad antifungal and antibacterial activity of a new actinomycete (S. albovinaceus) strain no.10/2 was isolated from soil sample of Palestine and characterized. The medium composition for antifungal production for strain no.10/2 (S. albovinaceus) was optimized using shake-flask methodology. 1.25 % mannitol and 1 % malt extract were found to be best carbon and nitrogen sources respectively for growth and antifungal production. Similarly initial pH of 7.2, 10 % level of inoculum, incubation period of 96 h, and agitation in 250 ml bottom indented flask and medium to flask ratio of 1:10 (aeration) were found to be optimal. Optimization of medium and cultural conditions resulted in good increase in antifungal yield.