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In Vitro Evaluation of the Potential Use of Propolis as a Multitarget Therapeutic Product: Physicochemical Properties, Chemical Composition, and Immunomodulatory, Antibacterial, and Anticancer Properties

Authors: 
Soumaya Touzani,1 Walaa Embaslat,2 Hamada Imtara,1,3 Abdalsalam Kmail,3 Sleman Kadan,3 Hilal Zaid,3 Ilham ElArabi,1 Lyoussi Badiaa,1 and Bashar Saad3
ISSN: 
2314-6141
Journal Name: 
BioMed Research International
Volume: 
2019
Issue: 
4836378
Pages From: 
1
To: 
11
Date: 
Thursday, December 12, 2019
Keywords: 
Propolis, PBMNCs, IL6, IL10, TNF alpha
Abstract: 
Propolis is a resin that honeybees produce by mixing saliva and beeswax with exudate gathered from botanical sources. The present in vitro study investigated the potential use of propolis as a multitarget therapeutic product and the physicochemical properties, chemical composition, and immunomodulatory, antioxidant, antibacterial, and anticancer properties of a propolis extract from the northern Morocco region (PNM). Pinocembrin, chrysin, and quercetin were the main phenolic compounds of PNM as measured inHPLC. ThePNM showed significant inhibitoryeffects againstall tested Gram-positiveand Gram-negative strains and showed high antioxidant activities by scavenging free radicals with IC50 (DPPH�0.02, ABTS�0.04, and FRAP�0.04mg/ml). In addition, PNM induced a dose-dependent cytostatic effect in MCF-7, HCT, and THP-1 cell lines at noncytotoxicconcentrationswithIC50valuesof479.22,108.88,and50.54μg/ml,respectively.Theproductionoftumornecrosis factor-α(TNF-α)andinterleukin-6(IL-6)wasdecreasedinadose-dependentmannerinLPS-stimulatedhumanperipheralblood mononuclear cells (PBMNCs),whereas the productionof the anti-inflammatoryinterleukin-10 (IL-10) wasincreasedin a dosedependentmannerreaching15-foldcomparedtothelevelsmeasuredinuntreatedPBMNCs.Overall,theresultsshowedthatthe traditionally known multitarget therapeutic properties of the PNM seem to be mediated, at least in part, through cytostatic, antibacterial, and immunomodulatory effects.
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